Hi,
Don't forget that any room will have its own unique set of "modes" (based on how it reflects and absorbs different frequencies) that will cause resonances and/or cancellations of different frequencies, and these will change as the room fills up with squidgy, watery, sound absorbing bodies (i.e. People!). Hollow stages add another level of complication .....
One of the jobs of a good sound man is to neutralise that for you and get you the right tonal balance for the front of house sound (you stage sound may be not as good, but in the sound man you must trust). If on your own, the global EQ settings in SetList mode could be your friend if you need to cut or boost frequencies (note cutting is usually best if you can achieve the balance with that).
You will also find that some patches are noticeably louder than others, and adjustment is needed to get the right overall balance across a set (again doing this in setlist for different sets is worthy of considering rather than tweaking patches - the next set could have a different set of patches and you won't want to keep tweaking patches for each set). The loudest sounds should be brought down as required to the level of the quietest or whatever relative difference is needed. Leave it to the sound man to get the overall volume in the mix. Avoid the onstage sound wars where everybody keeps turning up - get the loud buggers to turn down (we know the usual suspects

).
I find CX-3 to be way louder than other engines and struggle to get EPs to the same level, so CX-3 comes down in comparison.